Involvement of the GABAergic System in Dimethoate-induced Intoxication
نویسندگان
چکیده
منابع مشابه
Involvement of GABAergic System in Increased Pentylenetetrazole-Induced Seizure Threshold in Cholestatic Mice
Gamma-aminobutyric acid (GABA) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. Pentylenete-trazole (PTZ), a convulsant agent, partly acts via anion channel of GABAA receptor. Ivermectin, an antiparasitic agent and a GABAA agonist, has anticonvulsant effect in animal seizure models. Cholestasis increases ...
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Objective: Insomnia is accompanied by several health complications and the currently used soporific drugs can induce several side effects such as psychomotor impairment, amnesia, and tolerance. The present study was planned to investigate the sleep prolonging effect of Pinus eldarica. Materials and Methods: Hydroalcoholic extract (HAE) of P. eldarica, its water fraction (WF), ethyl acetate frac...
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Serotonin specific reuptake inhibitors (SSRI) may induce antinociception however, the mechanism of this effect is not clear. SSRls increase 5-HT levels in neuronal synapses and facilitate serotonergic activity. In this study, therefore, the activity of para-chlorophenylalanine (pCPA), which reduces 5-HT release, and 5- hydroxy tryptophan (5-HTP), a precursor of 5-HT, were examined on the a...
متن کاملinvolvement of gabaergic system in increased pentylenetetrazole-induced seizure threshold in cholestatic mice
gamma-aminobutyric acid (gaba) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. pentylenete-trazole (ptz), a convulsant agent, partly acts via anion channel of gabaa receptor. ivermectin, an antiparasitic agent and a gabaa agonist, has anticonvulsant effect in animal seizure models. cholestasis increases the threshold of ptz-induce...
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ژورنال
عنوان ژورنال: Journal of Health Science
سال: 2007
ISSN: 1344-9702,1347-5207
DOI: 10.1248/jhs.53.527